Pharmaceutics

The sigma blade mixer is one of the most popular mixers used for mixing and kneading high viscosity materials. It belongs to the family of double arm kneader mixers. It is a commonly used mixer for mixing high-viscosity materials. Principle of Sigma Blade Mixer The principle involved in these mixers, wherein very viscous materials are … Read more

A ribbon mixer blender is a light-duty blender mainly used for easy-to-mix powder components that are pre-processed, like dried granules and pre-sieved powders. It is a low-shear mixer and is mostly used for solid-solid mixing. Solid-liquid mixing can also be achieved when a high shearing force is not desired. It occupies less headroom space than … Read more

There are three popular shapes of twin shell blenders (also known as a tumble blender), namely; the V-blender, the double cone blender, and the slant cone blender. Tumble type blending is most suited for products of uniform particle size and density, and where requirements for fast, thorough cleaning are desirable for sanitary applications. The V-blender … Read more

Mixing is a common process step in the manufacture of products for industries such as healthcare, food, chemical, cosmetics, detergents, fertilizers, and plastics. The double cone blender (DCB) is used to produce a homogeneous solid-solid mixture. Principle of Double Cone Blender Double cone blenders are most often used for dry blending of free solids. The … Read more

In general, mixing involves one or more of the following mechanisms: Convective Mixing: Convective mixing is the process of transferring groups of particles in bulk from one part of a powder bed to another. It is also known as micro-mixing and is regarded as analogous to bulk transport. Depending on the type of mixer employed, … Read more

Factors affecting mixing: There are factors that can influence the efficiency of mixing, leading to the non-uniform distribution of materials, which can result in inaccurate dosage production. These factors are as follows: (i) Material density: If the mixture components are of different densities, the denser material will sink through the lighter one, the effect of … Read more

(i) Dry mixing: Mixing helps various powders to be mixed in varying proportions prior to granulation or tableting. Dry mixing of the materials makes them suitable for direct compression into tablets.(ii) Product features: The mixing helps to deliver an accurate dosage that has an acceptable appearance and texture, or to maintain formulation stability for the … Read more

Objectives of mixing in Pharmacy The aim of mixing is to ensure that there is uniformity of composition between the mixed ingredients that represent the overall composition of the mixture. The primary objective of mixing is to make a homogeneous product using the minimum amount of energy and time.The other objectives are as follows: (i) … Read more

In pharmaceutical processing, mixing involves certain heterogeneous components to be manipulated with the intent to make them more homogeneous. The term “mixing” is defined as a process that results in the randomization of dissimilar particles within a system. Mixing is defined as an operation in which two or more components in a separate, roughly mixed … Read more

Freeze-drying or freeze dryer, also called lyophilization, is a process in which water is frozen, followed by its removal from the sample, initially by sublimation followed by desorption. The equipment used to dry solutions or suspensions at or below freezing points of liquids is called a freeze dryer or lyophilizer. This drying process is utilized … Read more