Solubility of liquids in liquids

SOLUBILITY OF LIQUIDS IN LIQUIDS

Binary Solutions It is very common for two or more liquids to be mixed to make a solution. Therefore, we need to know what liquids can be mixed without precipitation. Examples of pharmaceutical solutions of liquids dissolved in liquids are hydroalcoholic solutions, aromatic waters, spirits, elixirs, lotions, sprays, and some medicated oils that contain a … Read more

Diffusion principles in biological systems

Matter moves by diffusion along energy gradients from areas of high concentration to areas of lower concentration. The rate of diffusion depends on temperature, the size of the particles, and the size of the concentration gradient. In biology, the selectively permeable cell membrane creates two special forms of diffusion, namely, osmosis for the diffusion of … Read more

Factors influencing solubility of drugs

SOLUBILITY OF DRUGS

Factors influencing solubility: The solubility of most solid solutes is significantly affected by temperature. When some solid dissolves in a liquid, a change in the physical state of the solid analogues (melting) takes place. Heat is required to break the bonds holding the molecules in the solid together. At the same time, heat is given … Read more

What is a solubility

Solubility is the ability of one substance to fully dissolve in another substance under specified conditions. The word soluble comes from the fourteenth century, from the Latin word ‘solvere’ meaning to dissolve. The concentration of a solution is usually quoted in terms of the mass of the solute dissolved in a particular volume of solvent. … Read more

Effervescent granules

Effervescent granules

Preparation of effervescent granules Effervescent granules are prepared by two methods: 1) Heat method 2) Wet method Heat Method: A large porcelain or stainless steel evaporating dish is placed over a boiling water bath. Sufficiently hot before placing the powder for the liberation of water from crystallization from citric acid. All the ingredients are powdered, … Read more

What are the Nasal preparations

Nasal preparations are Nasal drops, nasal sprays, nasal powder, and nasal washes. Nasal drops: Nasal drops are monophasic liquid dosage forms, the aqueous solutions of drops, instilled into the nose with the help of a dropper. The oil vehicle is not used for preparation, it is used for long periods it inhibits the movement of … Read more

Classification of suppository bases

suppository bases

Suppositories are solid dosage forms of a medicament for insertion into body cavities other than the mouth. They may be inserted into the rectum, vagina, or nasal cavity. Suppositories are available in different shapes, sizes, and weights. Suppositories are used to produce local, systemic, and mechanical action. Suppository Bases: These are used to prepare suppositories … Read more

Suppositories, preparation of suppositories

Suppositories, preparation of suppositories

Suppositories: “Suppositories are semisolid dosage forms of a medicament for insertion into body cavities other than mouth”. Preparation of suppositories Suppositories are prepared by the following methods Rolling method: It is an ancient method of preparing suppositories. The suppository base is rolled and then the desired shape is given with the hand. This is not … Read more

Method of preparation of paste

Paste are prepared similarly to the process of ointment. That is: 1. Trituration Method 2. Fusion Method The trituration method is used mainly in those cases where the base is liquid (or) semi-solid. The fusion method is used when the base is semi-solid (or) solid. (i) Trituration method: Already explained in the ointment topic. (ii) … Read more