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Solubility is the ability of one substance to fully dissolve in another substance under specified conditions. The word soluble comes from the fourteenth century, from the Latin word ‘solvere’ meaning to dissolve. The concentration of a solution is usually quoted in terms of the mass of the solute dissolved in a particular volume of solvent. … Read more
Preparation of effervescent granules Effervescent granules are prepared by two methods: 1) Heat method 2) Wet method Heat Method: A large porcelain or stainless steel evaporating dish is placed over a boiling water bath. Sufficiently hot before placing the powder for the liberation of water from crystallization from citric acid. All the ingredients are powdered, … Read more
Nasal preparations are Nasal drops, nasal sprays, nasal powder, and nasal washes. Nasal drops: Nasal drops are monophasic liquid dosage forms, the aqueous solutions of drops, instilled into the nose with the help of a dropper. The oil vehicle is not used for preparation, it is used for long periods it inhibits the movement of … Read more
Suppositories are solid dosage forms of a medicament for insertion into body cavities other than the mouth. They may be inserted into the rectum, vagina, or nasal cavity. Suppositories are available in different shapes, sizes, and weights. Suppositories are used to produce local, systemic, and mechanical action. Suppository Bases: These are used to prepare suppositories … Read more
Suppositories: “Suppositories are semisolid dosage forms of a medicament for insertion into body cavities other than mouth”. Preparation of suppositories Suppositories are prepared by the following methods Rolling method: It is an ancient method of preparing suppositories. The suppository base is rolled and then the desired shape is given with the hand. This is not … Read more
Paste are prepared similarly to the process of ointment. That is: 1. Trituration Method 2. Fusion Method The trituration method is used mainly in those cases where the base is liquid (or) semi-solid. The fusion method is used when the base is semi-solid (or) solid. (i) Trituration method: Already explained in the ointment topic. (ii) … Read more
Types of Ointment, Ointments are classified as: 1. According to their therapeutic properties. 2. According to their therapeutic use. Classification of ointment bases Also, read: Evaluation of the stability of suspensions
Ointment Preparation of ointment: Ointments are soft and semi-solid preparations meant for external application to the skin (or) mucous membrane. They usually contain a medicament, dissolved, suspended (or) emulsified in an ointment base. These are used for emollient and protective purposes. Eg: Compound benzoic acid ointment, calamine ointment, etc. Methods of Preparation of Ointment 1. … Read more
The following method are commonly used for evaluating the physical stability of suspensions Methods of Physical Stability of Suspensions Sedimentation Method The measurement of sedimentation volume is the most important parameter in the evaluation of the stability of suspensions. it is determined by keeping a measured volume of the suspension in a graduated cylinder in … Read more
Suspension are the biphasic liquid dosage form of medicament in which finely divided solid particles ranging from 0.5 to 5.0 microns are dispersed in a liquid (or) semisolid vehicle. Good qualities of a suspensions Formulation of Suspension Thickening agents are classified into three major groups: Polysaccharides: two types of polysaccharides are used a. Natural Polysaccharides: … Read more