What are aminoglycosides?
Aminoglycosides antibiotics are classified as broad-spectrum antibiotics, they are used for the treatment of serious systemic infections caused by aerobic Gram-negative bacilli.
They are polycationic compounds that contain an aminocyclitol, with Cyclic amino-sugars attached by glycosidic linkages.
![Aminoglycosides antibiotics gentamycin](https://pharmacygyan.com/wp-content/uploads/2021/06/image-3-1024x402.png)
![Aminoglycosides antibiotics gentamycin](https://pharmacygyan.com/wp-content/uploads/2021/06/pexels-chokniti-khongchum-3938023-1024x684.jpg)
Chemistry of Aminoglycosides:
The aminoglycoside antibiotic is the term aminoglycoside-aminocyclitols. They are incorporate amino-sugar with six-membered amonocyclitorings, cyclic carbon rings functionalized with amino and hydroxyl groups.
![Aminoglycosides antibiotics Amino sugar portion](https://pharmacygyan.com/wp-content/uploads/2021/06/image-4-1024x362.png)
Some membered of the group of antibiotics such as streptomycin does not have any sugar components.
![Aminoglycosides antibiotics](https://pharmacygyan.com/wp-content/uploads/2021/06/image-5.png)
The antibiotics which are very important for clinically used are generally subdivided into two groups such as
Compounds contain 2-deoxystreptamine aminocyclitol ring and that do not.
The 2-deoxystreptamine –containing antibiotics are further classified 2 group such as the aminocyclitol is substituted with amino sugar at the position 4 and 5 or 4 and 6 and presence of pentose at the position 5 ( neomycine).
![Aminoglycosides antibiotics](https://pharmacygyan.com/wp-content/uploads/2021/06/image-6.png)
The best tolerated antibiotics are the 4, 6- disubstituted deoxysteptamine compound such as GENTAMYCIN
![gentamycin](https://pharmacygyan.com/wp-content/uploads/2021/06/image-8.png)
Also, check our other topic related to SAR of Aminoglycosides