What are aminoglycosides?
Aminoglycosides antibiotics are classified as broad-spectrum antibiotics, they are used for the treatment of serious systemic infections caused by aerobic Gram-negative bacilli.
They are polycationic compounds that contain an aminocyclitol, with Cyclic amino-sugars attached by glycosidic linkages.
Chemistry of Aminoglycosides:
The aminoglycoside antibiotic is the term aminoglycoside-aminocyclitols. They are incorporate amino-sugar with six-membered amonocyclitorings, cyclic carbon rings functionalized with amino and hydroxyl groups.
Some membered of the group of antibiotics such as streptomycin does not have any sugar components.
The antibiotics which are very important for clinically used are generally subdivided into two groups such as
Compounds contain 2-deoxystreptamine aminocyclitol ring and that do not.
The 2-deoxystreptamine –containing antibiotics are further classified 2 group such as the aminocyclitol is substituted with amino sugar at the position 4 and 5 or 4 and 6 and presence of pentose at the position 5 ( neomycine).
The best tolerated antibiotics are the 4, 6- disubstituted deoxysteptamine compound such as GENTAMYCIN
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