What is aminoglycosides?

Aminoglycosides are classified as broad-spectrum antibiotics, their greatest usefulness lies in the treatment of serious systemic infections caused by aerobic gram-negative bacilli.

They are the polycationic compounds that contain an aminocyclitol, usually 2-deoxystreptamine, or streptidine in streptomycin and related compounds, with cyclic amino-sugar attached by glycosidic linkages.

Some of the amino glycoside antibiotic as follows;

  1. Streptomycin
  2. Gentamycin
  3. Neomycin
  4. Kanamycin
  5. Netilmicin
  6. Tobramycin
  7. Paromomycin


Since they include not only amino-sugars, but also six-membered aminocyclitorings, cyclic carbon functionalized with amino and hydroxyl groups, aminoglycoside antibiotics are more properly referred to as aminoglycoside-aminocyclitols.

Amino sugar portion
Amino cyclitol ring -centrally placed hexose ring

Despite the fact that certain members of the group, such as streptomycin, do not have a sugar portion, the term aminoglycosides is more commonly used.

Streptomycin Sulphate

Antibiotics that contain 2-deoxystreptamine are further divided into two classes depending on whether the aminocyclitol is substituted with amino sugars at positions 4 and 5 or 4 and 6. The existence of a pentose 5 neomycin is also a distinguishing feature of the former.

Neomycin Sulphate


The aminoglycosides function directly on the bacterial ribosome to prevent protein synthesis from beginning and to interfere with ribosome often causes genetic code misreading mutations, which are thought to be caused by unique amino-acyl RNAs failing to recognise the proper codons on messenger RNA (mRNA).

15 thoughts on “Aminoglycosides”

  1. Resources such as the one you mentioned right here will be extremely helpful to myself! Ill publish a hyperlink to this web page on my individual blog. Im positive my site guests will locate that quite beneficial.

  2. I like the valuable information you provide in your articles. I’ll bookmark your blog and check again here regularly. I am quite sure I’ll learn many new stuff right here! Good luck for the next!

  3. I found your blog site on google and verify a few of your early posts. Continue to keep up the superb operate. I just extra up your RSS feed to my MSN Information Reader. Seeking ahead to studying more from you later on!

  4. You must know, your post goes to the center in the issue. Your clearness leaves me wanting to know a lot more. merely so you know, i will instantly grab your feed to keep up to date with your website. Sounding Out thanks is purely my little way of saying bravo for a wonderful resource. Accept my nicest wishes for your inflowing article.

  5. Fantastic job here. I seriously enjoyed what you had to say. Keep heading because you absolutely bring a new voice to this subject. Not many people would say what youve said and still make it interesting. Properly, at least Im interested. Cant wait to see much more of this from you.


Leave a Comment