Pharmacological screening methods QB & Blueprints B pharmacy 8 sem.

Long essay 10 marks

Pharmacological screening methods

1. Enumerate methods to evaluate antidepressant activity of an agent. Discuss two in vivo methods.
2. Enlist methods to evaluate anti-diabetic activity of an agent. Discuss two in vivo method.
3. Enumerate methods to evaluate nootropics activity of an agent. Discuss one in vivo method.
4. Explain any two in-vivo screening methods for sympatholytic agents.
5. Enumerate methods to evaluate analgesic activity of an agent. Discuss two in vivo method
6. Describe two in-vivo methods to screen central analgesic activity
7. Describe any two methods to screen antiarrhythmic drugs.
8. Enumerate methods to evaluate anti-inflammatory activity of an agent. Discuss one in vivo method
9. List the various methods used in preclinical evaluation of sympathomimetic agents. Discuss two in-vivo methods.
10. Enumerate various methods to evaluate a compound for anti-diabetic activity. Explain two in-vitro methods and the chemically induced diabetes in rat.
11. List the various methods used in preclinical evaluation of anti-cancer agents. Discuss two in-vivo methods.
12. Enlist the methods to evaluate skeletal muscle relaxant activity. Discuss two in vivo method
13. List out the various screening methods for Antihypertensive drugs. Discuss one In-vitro & One In-vivo method.
14. Enlist methods to evaluate Parasympatholytics activity of an agent. Discuss two screening methods.
15. Explain any three in-vivo screening methods for anti-hypertensive agents.
16. Explain two in-vivo Preclinical Screening methods for Anti-pyretic drugs
17. Enlist various Preclinical Screening methods for Anti-inflammatory drugs. Explain two in-vivo methods.
18. Describe two various screening methods for Parasympathomimetics drugs.
19. Explain the any three Pre clinical Screening methods for Anti-cancer drugs
20. Describe three in-vivo screening methods for Sympathomimetic drugs.
21. Enlist methods to evaluate antihypertensive activity of an agent. Discuss two in vivo methods
22. Enumerate and explain various Preclinical Screening methods for Antipsychotic drugs.
23. Describe various screening methods for Sympathomimetic drugs. Explain on model in detail.
24. Enlist methods to evaluate anti-arrhythmic activity of an agent. Discuss two in vivo methods.
25. Explain any two in-vivo screening methods for skeletal muscle relaxants agents.
26. Enlist various methods to evaluate a compound for anti-cancer activity. Explain two in vivo methods
27. Describe any three screening models for Parasympatholytics drugs.
28. List the methods to screen antipsychotic activity. Discuss two in-vivo methods.
29. List the commonly used methods to screen an agent for skeletal muscle relaxants agents. Discuss two in-vivo methods.
30. List out various methods to evaluate a compound for anti-inflammatory activity. Explain two in-vivo methods.

Long essay 5 marks

1. Explain different methods for collection of blood in laboratory animals.
2. Describe the use to transgenic animals in preclinical screening.
3. Explain on method for screening local anesthetics.
4. Describe the two different screening methods for Antidiabetic activity.
5. In brief describe research hypothesis. Explain any two screening methods for coagulants
6. Explain any two screening methods for analgesics.
7. Explain significance of statistical analysis of one way ANOVA.
8. Explain constitution of IAEC and mention their role.
9. Discuss any two preclinical screening methods for nootropics models
10. Describe various blood collection methods of laboratory animals.
11. Explain any two preclinical screening methods for Parasympatholytics activity.
12. Explain any two preclinical screening methods for Antiulcer activity.
13. Enlist the various screening methods for Anti-arrhythmic drugs. Explain any one model.
14. Enlist the various screening methods for Anti-diabetic drugs. Explain any one model.
15. Explain the Significance of Statistical analysis of Student t test.
16. Mention the objectives of CPCSEA. Write the composition and responsibilities of IAEC.
17. Enlist different screening methods for coagulants. Explain any one in vivo method.
18. Explain one screening method for anti-arrhythmic agents.
19. Explain one screening method for anti-inflammatory activity.
20. Explain one screening method for anti-depressant
21. Describe one screening model for anticoagulants.
22. Explain the use of mutant animals in preclinical screening.
23. Describe the techniques of anaesthesia in laboratory animals.
24. Explain one screening method for sympathomimetic.
25. Explain one method to screen anti-ulcer activity.
26. What is the difference between student t test and one way ANOVA?
27. What are the commonly used methods to screen an agent for skeletal muscle relaxation?
28. Describe the significance of laboratory animals in pharmacological screening methods.
29. Describe any two screening methods for anti-ulcer activity.
30. Describe one in-vivo screening model for anti-epileptic drug.
31. Describe one in-vivo screening model for local anaesthetics.
32. Explain the high fat diet model for screening of anti-atherosclerotic agents.
33. Describe one way ANOVA.
34. Briefly explain breeding methods of laboratory animals.
35. Describe one screening method for anti-aggregatory activity.
36. Describe techniques of anaesthesia in laboratory animals.
37. Explain research hypothesis.
38. Discuss one screening method for anticoagulants
39. Explain one in vivo screening method for anti-hyperlipedmics.
40. In brief explain maintenance of laboratory animals as per CPCSEA guidelines?
41. What are the techniques used for anaesthesia in laboratory animals?
42. Explain any one screening method for anti-arrhythmic agents.
43. Explain one method to screen antipyretic activity.
44. Explain the applications of transgenic animals in pharmacology research.
45. Describe one in-vivo screening model for anti-asthmatics.
46. List various in-vivo methods to screen analgesic agents and discuss any one method
47. Explain the significance of statistical analysis of student T test.
48. What is Euthanasia? Describe different methods of Euthanasia.
49. Explain any one screening method for anti-cancer agents.
50. Explain significance of statistical analysis of student‘t’ test
51. Explain any two preclinical screening methods for Antidepressant activity.
52. Describe any one preclinical screening method for diuretic activity.
53. Describe different routes of drug administration in lab animals.
54. Describe different routes of drug administration in laboratory animals
55. What are the functions of institutions animal ethics committee?
56. Explain one screening methods for anti-asthmatic activity.
57. Describe one in-vivo screening method for sympathomimetic activity.
58. Discuss one in-vivo method for Screening antiulcer activity.In brief explain ANOVA.
59. Explain techniques for collection of blood in laboratory animals.
60. What are screening methods for parasympathomimetics?
61. Explain significance of sham negative and positive control group.
62. Explain different screening methods for anti-coagulants. Explain any one in vivo method.
63. Write a brief note on Maintenance of Laboratory Animals.
64. Describe any two preclinical screening methods for anti-aggregatory drugs.
65. Describe the use of Transgenic animals in Preclinical screening methods
66. Explain any two preclinical screening methods for Anti-Parkinsonism activity.
67. Application of mice as laboratory animal.
68. Explain any one screening method for anti-dyslipidemic activity.
69. Explain one screening method for anti-asthmatic activity
70. Enlist and explain any two preclinical screening methods for antiepileptic activity.
71. Enumerate any two preclinical screening methods for local anaesthetics.
72. Explain any two preclinical screening methods for anti-hyperlipidemia activity.
73. Describe two screening methods for anti-asthmatic activity.
74. Explain any two preclinical screening methods for coagulant activity.
75. Describe student-t-test and its significance.
76. Write a brief note on Maintenance of Laboratory Animals.
77. Explain two preclinical screening methods for Alzheimer’s disease.
78. Explain any one preclinical screening methods for Skeletal muscle relaxants.
79. Describe any two preclinical screening methods for analgesic activity.
80. Discuss one screening method on nootropics
81. Describe one in vivo preclinical method on local anaesthetics.
82. Explain one screening method for antipyretic activity.
83. Explain the different methods involved in breeding of laboratory animals
84. Discuss one screening method for anti-diabetic activity.
85. Explain rationale in selection of animal species and sex in experimental study.
86. Explain any one screening method anti-epileptic agents.
87. Explain one screening method for coagulants.

Short answers 2 marks

1. What is the significance of sham negative group?
2. What are the methods used for preparations of drugs suspension.
3. Enlist the methods for screening anti-ulcer activity.
4. Application of mutant animals.
5. What are the methods for screening of analgesic activity?
6. Mention the screening methods for anti-asthmatics.
7. List the screening methods for drugs acting on eye.
8. Application of transgenic animals.
9. What is one way ANOVA?
10. Mention screening methods for sedative agents.
11. What are the techniques for collection of blood samples in laboratory animals.
12. What are different techniques for euthanasia?
13. Different methods for screening analgesics
14. What are the rationales for selection of animal species?
15. Briefly explain the on the study designs involved in pre-clinical experiments.
16. Define research hypothesis.
17. Define hypothesis with example.
18. What are pharmacological uses of rat as laboratory animals?
19. List out different routes of drug administration in laboratory animals?
20. Mention the different species and strains of animals used in laboratory?
21. What method used for preparations of drugs suspension with examples.
22. Application of transgenic animals.
23. List out different methods for screening of anti-inflammatory activity.
24. Define Sedative and hypnotics.
25. Explain the preparation of drug solution regarding to various solvents used.
26. Enlist preclinical screening methods for anti-inflammatory activity.
27. Enlist preclinical screening methods for skeletal muscle relaxants.
28. Mention the screening methods for diuretics.
29. Mention the list of screening methods for anti-ulcer activity.
30. What different method used for screening anti-epileptic activity.
31. Write a short note on ANOVA.
32. Explain Graphical representation of data
33. Mention the screening methods for hypnotic activity.
34. Short note on review of literature.
35. List out different techniques for euthanasia?
36. List the screening methods for drugs acting on eye.
37. Enlist various techniques for collection of Blood Sample.
38. What is OECD? Briefly describe breeding techniques.
39. List out the screening models for analgesic activity.
40. Explain the preparation of drug solution in regard with various solvents used.
41. Explain the mechanism of chemical induced convulsions for screening of Anti-epileptic drugs.
42. Mention the screening methods for anti-ulcer drugs.
43. Mention the list of screening methods for sedatives and hypnotic activity.
44. Enlist methods to screen anti-hypertensive activity
45. Enlist the various screening methods for Anti-inflammatory drugs.
46. Enlist the various screening methods for Ant-iasthmatic activity.
47. Explain the Possible ways of Graphical representation of a data.
48. Enumerate the different screening methods for Parasympatholytics.
49. What are Parametric and nonparametric tests?
50. Mention the screening methods for drugs acting on eye.
51. Enlist different methods for screening of type-2 Anti-diabetic activity.
52. What is research hypotheses?
53. Enumerate different techniques for anaesthesia in laboratory animals.
54. Enlist models used to screen for hypnotic activity.
55. What are different routes of drug administration in laboratory animals?
56. Application of transgenic animals.
57. Mention different methods for screening anti- Alzheimer’s activity?
58. What are the rationales for selection of animal species?
59. What is review of literatures?
60. Examples for mydriatics and miotics.
61. What is student t test?
62. What are the methods for review of literatures?
63. What are different techniques for euthanasia in laboratory animals?
64. Give full form of CPCSEA and OECD?
65. Enlist different methods for screening nootropics?
66. What are the rationales for selection of animal species?
67. Write the full form of IAEC and OECD.
68. What are pharmacological uses of guinea pig as laboratory animal?
69. What are the rationales for selection of animal species?
70. Mention the composition of IAEC.
71. Mention the different species and strains of animals used in laboratory?
72. What are different routes of drug administration in laboratory animals?
73. Mention the screening methods for hypnotics.
74. Rationale for selection of animal species in preclinical studies.
75. Uses of rabbit in experimental pharmacology.
76. What is the significance of sham negative grou
77. How do you screen the analgesic agents?
78. Mention screening methods for sedative agent
79. What are the objectives of OECD guidelines?
80. Enlist preclinical screening methods for diuretics
81. Explain the possible ways of Graphical representation of data
82. What are parametric and non-parametric tests?
83. Enlist preclinical screening methods for diuretics
84. Explain the possible ways of Graphical representation of data.
85. What are parametric and non-parametric tests?
86. Mention the screening methods for anti-diabetic drugs.
87. Mention the list of screening methods for hypnotic activity.
88. What different models used for screening glaucoma activity?
89. Significance of Student –t-test.
90. Explain study design.
91. What are pharmacological uses of mice as laboratory animal?
92. What are experimental uses of rabbit?
93. Name the different methods used for screening of Parasympatholytics?
94. What are different techniques for euthanasia in laboratory animals?
95. What are the techniques for collection of blood samples?
96. Mention the screening methods for anti-asthmatics.
97. List out the methods to screen anti-epileptic agents?
98. Mention different species and strains of animals used in laboratory.

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