Species differences are seen in biotransformation and conjugation Xenobiotics.
2. PHYSIOLOGICAL FACTORS
- SEX DIFFERENCES
- NUTRIOTIONAL STATUS
- HORMONAL IMBALANCE
- FREQUENCY AND ROUTE OF ADMINISTRATION
- PROTEIN BINDING OF DRUG
4. ENVIRONMENTAL FACTORS
These are the chemical that increases the activity and ability of the enzyme which are Help for metabolism ex: cigarette smoke, alcohol, and barbiturates.
These are the chemicals which are decrease are activity and ability of the enzyme which help For drug metabolism. Ex: DDT, organophosphate insecticides, heavy metals(mercury, cobalt, tin, Nickle arsenic)
Stereochemistry of the drugs also affect the drug metabolism by a different enzyme
•(-)quinine treats malaria fever but (+) quinine does not.
•D (+) glucose gets easily metabolized to give CO2 and H2O but D(-) glucose does Not metabolize easily.