Immunodeficiency and Omenn syndrome
X-Linked Immunodeficiency with Hyper Immunoglobulin M Hyper-IgM was the initial term for the condition (HIGM). The most frequent type (XHIGM or HGM1), on the other hand, is passed down as an X-linked recessive characteristic. On activated T cells, people with HIGM lack a functional CD40 ligand (CD40L). Switching between antibody classes necessitates CD40L activation. These … Read more