Table of Contents
Pharmaceutical Organic chemistry-2 B pharmacy 3-semester Questions Bank
This Organic chemistry Questions bank released by rguhs bangalore, it contains all the important questions according to syllabus and questions pattern are based on PCI regulations.
Unit 1 benzene and its derivatives Organic chemistry Questions bank
10 marks
- Define activating and deactivating groups with examples. Discuss the Mechanism of Nitration and sulphonation of benzene.
- Explain the mechanism of halogenation of benzene. Halogens are deactivating Group but ortho & para director. Give reasons.
- Define the term ‘electrophilic aromatic substitution reaction”. Discuss the Effect of substituent’s on reactivity. Explain the mechanism of Friedel-Craft’s Alkylation with their limitations.
- What is electrophilic aromatic substitution reaction? Classify substituent Groups with examples, Explain the mechanism of Friedel-Craft’s acylation.
- What is Electrophilic aromatic substitution reaction? Discuss the mechanism of Nitration and halogenations of benzene.
- Give the general mechanism of electrophilic aromatic substitution reaction with suitable example, Discuss the orientation effect of i) Hydroxyl group in phenol ii) Nitro group in benzene.
5 marks
- Explain the reaction and mechanism of friedel craft’s alkylation with its Limitations.
- Explain the reaction and mechanism of halogenation of benzene
- Explain the reaction and mechanism of nitration of benzene.
- Explain the mechanism of Friedel-Craft’s acylation.
- Discuss the orientation effect of Hydroxyl and amino group in benzene.
- Explain the mechanism of Friedel-Craft’s acylation
- Explain why Halogens are deactivating but ortho para directions towards Electrophilic substitutions.
- Explain the reaction and mechanism of nitration of benzene.
- Define activating and deactivating groups with examples. Discuss the Mechanism of sulphonation of benzene.
- Explain the aromaticity, orbital picture and resonance structure of benzene.
- Define friedel craft’s alkylation. Explain the reaction and mechanism.
- Explain aromaticity and resonance of benzene.
2 marks
- Define the terms ‘aromaticity’ and ‘resonance’.
- Define electrophiles? Give two examples for electrophiles.
- Define activating group? Give examples.
- Define deactivating group? Give examples.
- What are ortho para directing groups? Give examples.
- Explain huckel’s rule of aromaticity
- Write the structure of DDT and BHC. List one use each of DDT and BHC.
- Write the structure and uses of DDT and cloramine
Unit-2 phenols, aromatic amines, and aromatic acids
10 Marks
- What are phenols? Give any three methods of preparation of phenol. Write a note on acidity of phenol.
- What are aromatic amines? Give any three methods of preparation of aromatic amines. Write a note on basicity of aromatic amines.
- What are phenols? Explain the of reactions of phenol. Discuss the effect of substituent’s on acidity of phenol.
- What are aromatic amines? Explain the of reactions of aromatic amines. Discuss the effect of substituent’s on basisity aromatic amines.
- What are aromatic acids? Give any three chemical reactions of benzoic acid. Write a note on substituents on acidity of aromatic acids.
- A)What are phenols? Explain acidity of phenols B) What are aromatic amines explain basisity of aromatic amines.
5 marks
- What is acidity discuss the effect of sustituent on acidity of aromatic acids
- What is basicity explain the basisity of aromatic amines tendency of a
- What are phenols Explain acidity of phenols
- Give three methods of preparation and three chemical reactions of Aromatic acids
- Write any three methods of preparation of aromatic amines. Give synthetic uses of aryl diazonium salts
- Define aromatic acid? Give four chemical reactions of benzoic acid
- Give the structure and uses of a) phenol b) o-cresol e) resorcinol d) a-napthol e) ß-napthol
- Define acidity explains the effects of substituents on acidity of aromatic acids.
- What are phenols? Discuss the acidity of phenols
- What are aromatic amines? Explain the basisity aromatic amines.
- Give any two methods of preparation and chemical reactions of aromatic acid.
- Give any two methods of synthesis of phenols. (Discuss the qualitative test of phenol
2 marks
- Give the structure and uses of phenol and o-cresol
- Give synthetic uses of aryl diazonium salts
- Give the structure and uses of a-napthol and resorcinol
- Give any two chemical reactions of benzoic acid
- Give the structure and uses of m-cresol and ß-napthol
- Give qualitative test of phenol
Unit 3 fats and oil Organic chemistry Questions bank
10 marks
- What are oils & fats? Give the classification of oils with examples. Enlist the analytical of fats and oils with their significance.
- Enlist analytical constants of oils and fats. Discuss in detail about acid valve And iodine value and give their significance.
- Explain drying, semidrying and non-drying oils with examples. Define lodine value. Give the principle involved in the determination of Iodine value (any one method)
- Explain drying, semidrying and non-drying oils with examples. Define acid value. Give the principle involved in the determination of acid value (any one method)
- Explain drying, semidrying and non-drying oils with examples. Define Saponification value. Give the principle involved in the determination of Saponification value (any one method)
- What are fatty acids? Explain significance and reactions of hydrolysis, hydrogenation, rancidity and drying of oils.
2 marks
- Describe any one method to determine Reichert Meissl (RM) value with its significance
- Describe any one method to determine Acetyl value with its significance
- Explain the Saponification and Rancidity of oils and their significance.
- Explain significance and reactions of hydrolysis and hydrogenation of oils and fats
- Describe any one method to determine iodine value with its significance
- Describe any one method to determine acid value with its significance
2 marks
- What are fatty acids? Give an example for saturated fatty acids.
- Give the pharmaceutical applications of fats and oils.
- Why oils are liquid and fats are solids at room temperature
- Define saponification value. Give its significance
- What do mean by Reichert Meissl (RM) value? Give its significance.
- Define rancidity and drying of oils
- Define acid value. Give its significance.
- Define acetyl value. Give its significance
- Classify fats and oils with examples
- Define lodine value. Give its significance
- Define lodine value. Give its significance
- What are fatty acids? Give an example for unsaturated fatty acids.
- Write the pharmaceutical applications of fats and oils
- Write the significance of hydrogenation of fats and oils
- Define rancidity? Give its significance.
- Give the compositions of fats and oils.
- Define saponification value. Give its significance
- Define lodine value. Give its significance
- Give the sources of fats and oils
Unit 4 Poly nuclear hydrocarbons
5 marks
- Outline the synthesis of Anthracene by Haworth’s method.
- Outline the synthesis of Napthalene by Haworth’s method.
- Define and classify poly nuclear hydrocarbons. Give four chemical reactions Of Anthracene
- Define and classify poly nuclear hydrocarbons. Give four chemical reactions Of naphthalene.
- Define and classify poly nuclear hydrocarbons. Give four chemical reactions Of Phenanthrene.
- Define poly nuclear hydrocarbons Give any two synthesis of anthracene.
- Define poly nuclear hydrocarbons Give any two methods of synthesis of Phenanthrene.
- Define poly nuclear hydrocarbons Give any two synthesis of naphthalene.
- Write the any two synthesis and reactions of phenanthrene.
- Write the any two synthesis and reactions of anthracene.
- Write the synthesis of anthacene and phenanthrene.
- Write the structure and medicinal uses of naphthalene, anthracene, Diphenylmethane and phenanthrene.
2 marks
- Write the structure and medicinal uses of diphenylmethane
- Write any two reactions of phenanthrene.
- Write any two reactions of Anthracene
- Write the structure and medicinal uses of phenanthrene derivatives.
- Write the structure and medicinal uses of triphenylmethane.
- Write any two reactions of phenanthrene
- Give the nitration reaction of naphthalene
- Give the nitration reaction of anthracene
- Give the halogination reaction of naphthalene
- Give them any one synthesis of naphthalene
- Give the structure and uses of one medicinally important phenanthrene derivatives.
- Define and classify poly nuclear hydrocarbons.
Unit 5 cycloalkanes
5 marks
- Discuss the stability of cycloalkanes.
- Explain Sache- Mohr theory and molecular orbital concept of cycloalkanes.
- What are cycloalkanes? Write any four methods of preparation
- Explain Bayer’s strain theory of cycloalkanes. What are its limitations?
- Write the any two methods of synthesis of cyclobutane and cyclopropane
- Give them any four chemical reactions of cyclopropane
- Give them any four chemical reactions of cyclobutane
- Discuss coulson and moffitt modifications of Bayer’s strain theory of cycloalkanes
- Define anglestrain? Discuss why higher cycloalkanes are more stable than lower members
- Give any four methods of synthesis of cycloalkanes.
- Explain ring opening reactions of cyclopropane.
- Describe Bayer’s strain theory. What are its limitations?
2 marks
- Define cycloalkane give two examples
- Define angle strain and tetrahedral angle.
- Give the reactions of cyclobutane
- What are coulson and moffitt modifications compound
- Write preparation of cyclohexane from aromatic compound
- How do you calculate the angle in cyclobutane
- Write wurtz’s synthesis of cycloalkane.
- Why lower cycloalkanes are unstable than higher cycloalkane give reason
- Give addition reactions of cyclopropanes
- What is Sache mohr’s theory
- How do you calculate the angle in cyclopropane
- How do you synthesize cycloalkanes from aromatic compounds