Advance-instumentaion-techniques

Advanced instrumentation techniques question bank & Blueprint

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Advanced instrumentation techniques question bank & Blueprint for B pharmacy 8 semester

Advanced instrumentation techniques question bank & Blueprint for B pharmacy 8 semesters is released by rguhs Bangalore, it contains all important questions, according to the syllabus. For Download the Questions bank click the download button given in below of this article.

Advance-instumentaion-techniques
instrumentation techniques question bank

Long essay 10 marks instrumentation techniques question bank

  1. Write the principle involved in NMR spectrometer. Add a note on factors affecting on
    Shielding and de -shielding in NMR Spectra.
  2. Explain the principle and working of TGA. (Thermal gravimetric analysis)
  3. Discuss in detail the validation parameter for bio analytical methods as per ICH
    guidelines.
  4. Explain the fundamental principles and instrumental arrangements of NMR. Write a
    detail note on Octant rule
  5. Discuss the principle and working of DTA. (Differential Thermal Analysis)
  6. Discuss background and principles of Bio analytical method validation as per USFDA
    regulations
  7. Discuss in detail various ionization techniques employed in the Mass Spectroscopy.
  8. Explain the principle and working of TGA. (Thermal gravimetric analysis)
  9. Write the principle involved in crystallographic studies by X- ray diffraction. Give the
    importance of Braggs law in X-ray diffraction spectroscopy.
  10. Explain instrumentation of Mass Spectrometer and its applications.
  11. Discuss background and principles of Bio analytical method validation as per USFDA
    regulations
  12. Explain the production and detection of X-rays by Debye scherrer method
  13. Write a note on coupling and decoupling methods and its significance in NMR
    Spectroscopy.
  14. Explain the production and detection of X-rays by Debye Scherrer method.
  15. Discuss concept of TQM. Add a note on ICH-EG guidelines.
  16. Explain the principle involved in the Electron impact of MALDI ionization
    techniques. Write its merits and demerits. Explain the Quadra pole mass analyzer.
  17. Define and derive the Braggs law and explain rotating crystal technique.
    Chemical ionization.
  18. Discuss in detail the validation parameter for bio-analytical methods as per USFDA.
    guidelines.
  19. Write a note on Coupling and Decoupling methods in NMR Spectroscopy
  20. Explain validation of analytical method of LC as per ICH guidelines
  21. Write the principle of differential scanning calorimeter. What factors are responsible?
  22. Write a note on Coupling and Decoupling methods in NMR Spectroscopy.
  23. Explain validation of analytical method of LC as per ICH guidelines
  24. Define validation; explain the types of process validation
  25. Write a note on coupling and decoupling methods and its significance in NMR
    Spectroscopy.
  26. Discuss concept of TQM. Add a note on ICH-EG guidelines
  27. Discuss the instrumentation and application of TGA
  28. Explain the principle involved in the Chemical ionization. Write the merit and
    demerits. Explain the working of Quadra pole and Ion trap mass analyzer.
  29. Discuss the principle and working of DTA. (Differential Thermal Analysis)
  30. Write the principle involved in the X-ray crystallography. Explain the importance of
    structural elucidation in X-ray diffraction spectroscopy

Short essay 5 marks instrumentation techniques question bank

  1. Explain chemical shift and factors influencing on Chemical shift.
  2. Discuss the instrumentation and application of DSC.
  3. Explain the methodology involved in the qualification of fluorimeter.
  4. Write a note on single crystal diffraction and powder diffraction.
  5. Classify different kinds of ELISA and explain each of them in details.
  6. Explain the methodology involved in the qualification of UV-VIS Spectrophotometer.
  7. Enlist different X-ray diffraction techniques and explain the any one detail.
  8. Describe the principle and procedure involved in the solid phase extraction.
  9. Explain the methodology involved in the qualification of GC.
  10. Write fragmentation process in Mass Spectroscopy.
  11. Describe the theory of Mass spectrometry
  12. Explain the methodology involved in the qualification of HPLC.
  13. Write the importance of Radio immune assay.
  14. Limitations and application of Radio Immuno Assay.
  15. Explain the various derivatization techniques in GC.
  16. Write the various applications of X-ray diffraction methods.
  17. Discuss the principle and application of DSC.
  18. Discuss in detail about the HPTLC technique
  19. Describe the rules for fragmentation of molecules in MS with suitable examples.
  20. Discuss the instrumentation and application of DSC.
  21. What is Chemical Shift? Explain with examples different factors influencing Chemical
    Shift.
  22. Discuss the identification powder diffraction pattern in X-ray diffraction spectroscopy.
  23. Classify different kinds of ELISA and explain each of them in details.
  24. Explain the methodology involved in the qualification of UV-VIS Spectrophotometer.
  25. Explain the principle and different methods of Radio Immuno Assay.
  26. Describe the principle and procedure involved in the solid phase extraction.
  27. What is theoretical plate, HETP, retention and asymmetry factor
  28. Discuss the principle and working of DTA.
  29. Describe the theory of Mass spectrometry
  30. Explain the methodology involved in the qualification of HPLC.
  31. Write the importance of Radio immune assay.
  32. Explain the concept of ELISA and its application as the diagnostic test for HIV.
  33. Explain validation parameter for electronic balance.
  34. Explain the terms of Chemical shift and Spin-Spin coupling, Coupling constant.
  35. Explain the chromatographic techniques and its applications
  36. Describe the principle and procedure involved in the solid phase extraction
  37. Explain Spin-Spin coupling and coupling constant.
  38. Discuss the instrumentation and application of DSC.
  39. Enlist the different X-ray Diffraction techniques and explain the application of X-ray
  40. diffraction.
  41. Explain the methodology involved in the qualification of UV-VIS Spectrophotometer.
  42. Describe the principle and procedure involved in the solid phase extraction.
  43. Discuss in detail cGmp guidelines according to CDER USFDA
  44. Discuss about design a qualification and describe the qualification GC.
  45. Explain the principle, advantages and requirements of Radio Immuno Assay.
  46. Define Chemical shift. Explain nuclear Over Hauser effect.
  47. Discuss the principle of NMR Spectroscopy.
  48. How are X-ray produced? What are modification of X-ray tube?
  49. Explain the principle and procedure involved in the liquid-liquid extraction.
  50. Explain the methodology involved in the qualification of GC.
  51. Describe the Radio Immunological assays and bioluminescence assay.
  52. Classify chromatographic methods and explain the instrumentation of HPLC
  53. What is theoretical plate, HETP, retention and asymmetry factor.
  54. Discuss the concept X-ray Crystallography.
  55. Briefly outline the instrumentation of Mass Spectrometer.
  56. State and derive the an equation for Braggs law.
  57. Explain the methodology involved in the qualification of HPLC.
  58. Explain the utilization of ELISA technology in the measurement of biological activities
  59. Write the various components, Limitations and application of Radio Immune Assay
  60. Explain validation parameter for electronic balance.
  61. Give a brief outline of principle of FT-NMR and CNMR
  62. Discuss in detail about the HPTLC technique.
  63. With a suitable diagram explain the construction and working of HPLC.
  64. Briefly outline the instrumentation of Mass Spectrometer.
  65. State and derive the an equation for Braggs law.
  66. Explain the methodology involved in the qualification of HPLC.
  67. Explain the utilization of ELISA technology in the measurement of biological activities
  68. Write the various components, Limitations and application of Radio Immune Assay
  69. Explain validation parameter for electronic balance.
  70. Enlist different ionizers used in MS and explain any one in detail.
  71. Discuss in detail about the HPTLC technique.
  72. Write the construction and working of HPLC.
  73. Explain the fragmentation pattern rules used in Mass spectroscopy.
  74. Explain the technique involved in thermal. Gravimetric analysis with suitable Examples
  75. Explain the different parts of Mass spectrometer with neat diagram.
  76. Explain the utilization of ELISA technology in the measurement of biological activities
  77. What are the factors to be considered during preparation of HPLC Analyses of drug
  78. products
  79. What is theoretical plate and explain any one detail.
  80. Discuss in detail the various detectors used in GC.
  81. Write note on bioluminescence assay, Enlist the application of ELISA.
  82. Explain the production and detection of X-rays by Debye Scherrer method.
  83. Explain the principle and instrumentation of NMR Spectroscopy.
  84. Write the principle of TGA. What factors are responsible for affecting TGA results
  85. Explain the terms of Chemical shift and Spin-Spin coupling, Coupling constant.
  86. Write the principle involved in the rotating crystal technique in X-ray diffraction
  87. spectroscopy.
  88. Explain the principle and different methods of Radio Immuno Assay.
  89. Explain the methodology involved in the qualification of HPLC.
  90. Describe the principle and procedure involved in the solid phase extraction.
  91. Explain the method involved in the qualification of
  92. Explain the various derivatization techniques in GC

Short answer 2 marks

  1. Enlist different ionizers used in MS.
  2. Define the Braggs law.
  3. Define and classify validation.
  4. Write the Limitations of Radio Immuno Assay.
  5. Differentiate between ELISA and RIA.
  6. Write applications of DTA.
  7. Important applications of IR.
  8. Write any one sampling technique of LC-MS.
  9. Name the ideal carrier gas used in Gas Chromatography
  10. What is HPTLC.?
  11. Solvent used in NMR Spectroscopy
  12. Applications of X Ray.
  13. Flame photometer
  14. ELISA.
  15. Define Radio Immuno Assay
  16. Spin-Spin coupling
  17. define Bragg’s law
  18. Important feature of qualification of UV-Visible.
  19. Classify different methods of Radio Immuno Assay
  20. HPTLC
  21. What is Shielding and De- shielding?
  22. What is single crystal diffraction.?
  23. Mention validation methods with examples
  24. Write the Limitations of Radio Immuno Assay.
  25. Application as the diagnostic test for HIV.
  26. Write its merits and demerits of HPLC.
  27. Write important applications of IR.
  28. Write sampling techniques of LC-MS.
  29. Qualification of UV Spectrophotometer.
  30. Detectors used in GC.
  31. Application of GC.
  32. Qualification of Fluorimeter.
  33. Define Singlet and Doublet.
  34. Applications of IR.
  35. Radio Immuno Assay
  36. Spin-Spin coupling
  37. What is plate theory and rate theory
  38. Important feature of qualification of UV-Visible.
  39. Define full validation and partial validation.
  40. Advantages of HPTLC.
  41. Classify different kinds of ELISA
  42. Define Singlet and Doublet.
  43. Define full validation and partial validation.
  44. Applications of IR.
  45. Radio Immune Assay.
  46. Qualification of IR Spectrophotometer.
  47. What is plate theory and rate theory
  48. Important feature of qualification of UV-Visible.
  49. Define Bragg’s law.
  50. Internal standard used in NMR.
  51. Factors influencing on Chemical Shift
  52. Write the concept of Miller indices
  53. Define Bragg’s law
  54. Name the detector used in Flame Photometer
  55. Qualification of IR Spectrophotometer
  56. Define ELISA and its uses
  57. Important feature of qualification of UV-Visible
  58. Application of GC
  59. Detection method methods in HPTLC
  60. Detectors used in HPLC
  61. Define quenching and give example
  62. Detector used in Flame Photometer.
  63. Define Singlet and Doublet.
  64. Enlist application of ELISA..
  65. Write the various components Radio Immune Assay
  66. Spin-Spin coupling
  67. What is plate theory and rate theory
  68. Enlist the ICH guidelines
  69. Define validation
  70. Advantages of HPTLC.
  71. Enumerate the application of HPTLC.
  72. Name the gases used in flame emission spectroscopy.
  73. Define Singlet and Doublet.
  74. Enlist the application of ELISA..
  75. Write the various components Radio Immune Assay
  76. Spin-Spin coupling
  77. What is plate theory and rate theory
  78. Define molecular ion and fragment ion
  79. Define validation
  80. Operational qualification
  81. Detectors used in GC.
  82. Define Coupling constant..
  83. What is Chemical Shift?
  84. Advantages of FT-IR Spectrophotometer
  85. Write the various components Radio Immune Assay
  86. Spin-Spin coupling
  87. What is rate theory?
  88. Installation qualification for UV
  89. Define validation
  90. Advantages of HPLC.
  91. What is Chemical shift? Write it significance
  92. Enlist the different X-ray Diffraction techniques.
  93. Define full validation & partial validation.
  94. Enumerate the different types of ELISA methods.
  95. Write importance of Radio Immuno Assay.
  96. Name the different derivatizations used in GC.
  97. Write the factors during preparation of HPLC Analyses drug products.
  98. Write sampling techniques of GC-MS.
  99. Define validation and explain different type of method validation
  100. 100.Detectors used in HPLC
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