Table of Contents
1.GENETIC FACTORS
Species differences are seen in biotransformation and conjugation Xenobiotics.
2. PHYSIOLOGICAL FACTORS
- AGE
- SEX DIFFERENCES
- PREGNANCY
- NUTRIOTIONAL STATUS
- DIET
- HORMONAL IMBALANCE
3.PHARMACODYNAMIC FACTORS
- DOSE
- FREQUENCY AND ROUTE OF ADMINISTRATION
- PROTEIN BINDING OF DRUG
4. ENVIRONMENTAL FACTORS
- PRESSURE
- TEMPRATURE
- ATMOSPHERE
- HUMIDITY
5.ENZYME INDUCER
These are the chemical that increases the activity and ability of the enzyme which are Help for metabolism ex: cigarette smoke, alcohol, and barbiturates.
6.ENZYME INHIBOTORS
These are the chemicals which are decrease are activity and ability of the enzyme which help For drug metabolism. Ex: DDT, organophosphate insecticides, heavy metals(mercury, cobalt, tin, Nickle arsenic)
7.STEREOCHEMICAL FACTORS
Stereochemistry of the drugs also affect the drug metabolism by a different enzyme
•(-)quinine treats malaria fever but (+) quinine does not.
•D (+) glucose gets easily metabolized to give CO2 and H2O but D(-) glucose does Not metabolize easily.