Factor affecting drug metabolism

1.GENETIC FACTORS Species differences are seen in biotransformation and conjugation Xenobiotics. 2. PHYSIOLOGICAL FACTORS AGE SEX DIFFERENCES PREGNANCY NUTRIOTIONAL STATUS DIET HORMONAL IMBALANCE 3.PHARMACODYNAMIC FACTORS DOSE FREQUENCY AND ROUTE OF ADMINISTRATION PROTEIN BINDING OF DRUG 4. ENVIRONMENTAL FACTORS PRESSURE TEMPRATURE ATMOSPHERE HUMIDITY 5.ENZYME INDUCER These are the chemical that increases the activity and ability of … Read more

Drug metabolism phase-1 and phase-2 metabolism

Phase-1 and Phase-2 drug metabolism Metabolism is a process which terminates the action of the drug and helps in its Excretion from the body. Drug metabolism is the process which describes biotransformation of drugs or nonessential Exogenous compounds in body so that they can be easily eliminated. Drug metabolism occur by 2 different ways PHASE … Read more

Introduction to Medicinal Chemistry

Medicinal chemistry is a discipline at the intersection of chemistry and pharmacology that involves the identification, synthesis, and development of new chemical entities that are suitable for medical or pharmaceutical use. Medicinal chemistry is an interdisciplinary science combining a variety of subjects such as organic chemistry, phytochemistry, pharmacology, toxicology, molecular biology, biochemistry, computational chemistry, physical … Read more

Aminoglycosides

What is aminoglycosides? Aminoglycosides are classified as broad-spectrum antibiotics, their greatest usefulness lies in the treatment of serious systemic infections caused by aerobic gram-negative bacilli. They are the polycationic compounds that contain an aminocyclitol, usually 2-deoxystreptamine, or streptidine in streptomycin and related compounds, with cyclic amino-sugar attached by glycosidic linkages. Some of the amino glycoside … Read more

Orientation of mono substituted benzene compounds towards electrophilic substitution reaction.

Orientation of mono substituted benzene compounds towards electrophilic substitution reaction.